The development of new vaccines is expensive and lengthy. So far, biosensors for monitoring the cell development in a cost-efficient and reliable way did not exist.

As part of the interdisciplinary research project BIOGRAPHY, the companies SAUERESSIG, Haydale, cellasys and AiCuris as well as Fraunhofer Institute for Biomedical Engineering are working on a method to print graphene color and proteins on a substrate in order to provide the breeding ground and measuring device for the cells. One advantage of the new biosensors is the possibility of online monitoring within the protected environment of the incubator. Measurements at different times can be made without damaging the cells.

The BIOGRAPHY biosensors can be used in cell biology, virology or biosensorics. Saueressig is providing decisive input for the development of the printing processes and the structuring of the printing tools.

Thanks to SAUERESSIGS’s directly engraved rotogravure printing rollers and a printing machine that was developed specifically for this purpose, electrically conductive and biocompatible graphenes could be printed on first substrates. FREE-1 is a printing machine by SAUERESSIG that was originally developed for rotogravure and flexo printing. It compromises a gravure and flexo printing mechanism as well as a drying unit. SAUERESSIG perfected the system; so complete sensors can be printed on the plant in future.

The corresponding gravure rollers are structured using picosecond lasers. That way, cells of sufficient sizes for the proteins can be obtained.

In printing the proteins, SAUERESSIG is drawing on the experiences of the BIOREEL research project. As part of this research project, the optimum microstructure for protein-printing and the most suitable substrate were researched.

“We are pleased with the current progress in all areas and are proud that the graphene color can already be printed in rotogravure printing.”, says Renate Warmers, head of the project BIOGRAPHY at SAUERESSIG.

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